Chemicals Likely to Impair Sense of Smell in Farmers

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 A new research has linked loss of smell in ageing farmers to over-interaction with chemicals contained in pesticides and weed killers.

The study showed a greater association with poor sense of smell especially with two insecticides – DDT and lindane, as well as four weed killers – alachlor, metolachlor, 2,4-D and pendimethalin.

The research which was conducted by a Michigan State University, in collaboration with researchers from the National Institute of Environmental Health Sciences and National Cancer Institute, was conducted as part of the national Agricultural Health Study with the National Institutes of Health, Environmental Protection Agency and the National Institute for Occupational Safety and Health.

“Studying farmers gives us more reliable data on pesticide exposures than if we had studied the general population,” said Honglei Chen, lead author and professor of epidemiology. “Because they use pesticides more and it is part of their job, they’re more likely to remember what pesticides they used and in cases of high exposures, report the specific events.

“Farmers reporting incidents, involving unusually high exposures to certain organochlorine insecticides such as DDT and herbicides including 2, 4-D, were more likely to have a poor sense of smell,” he said. “More research needs to be done, but some studies have linked these chemicals to Parkinson’s and possibly dementia too.”

Over 11,200 farmers were examined over a 20-year period and about 16 per cent of participants reported having experienced a high pesticide exposure event, or HPEE, such as a large amount of pesticide spilling on their body. Two decades later, they were asked if they suffered olfactory impairment, a partial to complete loss of sense of smell.

Farmers who reported an HPEE were 50 per cent more likely to report a poor sense of smell at the end of the study. The research also showed that an immediate washing with soap and water might mitigate risk. Compared to farmers who never experienced a high exposure event, those who did and washed within three hours, had about a 40 percent higher risk of having problems with smell. Those who waited four or more hours, saw their risk potentially double.

While poor sense of smell has been shown to be an early symptom of Parkinson’s and dementia, Chen said his study only addresses an association between pesticide exposure and impaired smell, not to neurodegenerative diseases.

“Olfactory impairment affects up to 25 per cent of our older population, and our understanding of what the consequences are is still very limited,” Chen said. “Studies have also suggested that older adults with a poor sense of smell are more likely to die earlier, so understanding the factors involved is very important.”

 

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